Santo Ângelo is a municipality located in northwestern Rio Grande do Sul state, Brazil. It has about 77,568 inhabitants (according to 2020 IBGE estimate) and the total area of the municipality is about 679 km². It borders Giruá to the north, and Entre-Ijuís to the south—it's linked to Santo Ângelo by the state road RS 344. The city is located 443 km (275 mi) from the state capital, Porto Alegre.
The local agriculture-economy produces and deals soy, corn, wheat, swine, sheep and cattle. Tourism in the city is primarily associated with the city's Jesuit history and the Jesuit Reductions in the nearby city São Miguel das Missões. The Angelopolitan Cathedral in downtown Santo Ângelo is the seat of the Roman Catholic Diocese of Santo Ângelo.
The city is served by Sepé Tiaraju Airport and is home to three institutions of higher education, Universidade Regional Integrada do Alto Uruguai e das Missões (URI), Faculdade CNEC Santo Ângelo and Instituto Federal Farroupilha (IFFar).