Apizaco is a city in Apizaco Municipality located near the geographic center of the Mexican state of Tlaxcala, approximately 25 minutes by car from the state's capital city of Tlaxcala. The city gets its name from the Nahuatl language words "ātl" (water), "pitzāhuac" (thin), and the suffix "co" (place), forming "Āpitzāco", or roughly "thin water place". Those seeking to reach the port of Veracruz by railroad from Mexico City must travel through Apizaco. The city began because of its location on this railroad.
Universities in Apizaco include the Technological Institute of Apizaco (Instituto Tecnológico de Apizaco), and most recently, the University of the Valley of Tlaxcala (Universidad del Valle de Tlaxcala)
The city's climate is temperate and arid. Temperature in the winter can fall below 0°C, and in the summer, it can reach in excess of 30°C.
The city is the second in importance after the capital city, Tlaxcala.