Khamis Mushayt or Khamis Mushait (Arabic: خميس مشيط, Ḫamīs Mušayṭ) is a city in south-west Saudi Arabia, located east of Abha, the provincial seat of the 'Asir Province, 1,300 kilometres (810 mi) 650 nautical miles from Dhahran and 884 kilometres (549 mi) from the national capital of Riyadh. It is the capital of the Shahran tribe in the Asir region.
It is fifth-largest city in Saudi Arabia after Riyadh, Jeddah, Mecca and Medina, with an estimated population of 1,353,000 as of 2017. Khamis Mushayt is noted for being the fourth largest trading center in Saudi Arabia, and is famous for its world-class military airbase.