Mayadin (Arabic: ٱلْمِيَادِين/ALA-LC: al-Miyādīn) is a town in eastern Syria. It is the capital of the Mayadin District, part of the Deir ez-Zor Governorate. Mayadin is about 44 kilometers southeast of Deir ez-Zor. The Euphrates River flows through the town. In the 2004 census, the population was 44,028, making it the second most populous town in the governorate.